Grand Rounds from International Lupus Centres `Catastrophic' antiphospholipid syndrome
Identifieur interne : 002542 ( Main/Exploration ); précédent : 002541; suivant : 002543Grand Rounds from International Lupus Centres `Catastrophic' antiphospholipid syndrome
Auteurs : P J Maddison [Royaume-Uni] ; C. Thorpe ; J R C. Seale ; W. Ahmed ; G S Whiteley [Royaume-Uni]Source :
- Lupus [ 0961-2033 ] ; 2000-09.
English descriptors
- Teeft :
- Active phase, Anticardiolipin, Anticardiolipin antibodies, Anticardiolipin antibody, Antiphospholipid, Antiphospholipid antibodies, Antiphospholipid syndrome, Arthritis rheum, Asherson, Catastrophic antiphospholipid syndrome, Clinical course, Clinical features, Clinical picture, Coagulation, Deep venous thrombosis, Distress syndrome, Erythematosus, Gastrointestinal features, Gwynedd rheumatology service, High degree, High dose, Hypercoagulable disorder, Intensive care, Intensive care unit, Liver function tests, Lung compliance, Lupus, Microangiopathic haemolytic anaemia, Motor neuropathy, Multiple organs, Neurological manifestations, Platelet count, Previous history, Progressive failure, Rheumatoid factor, Rheumatol, Syndrome, Systemic, Systemic lupus erythematosus, Thrombosis, Thrombotic, Thrombotic storm, Transient improvement, Vascular endothelium, Ysbyty gwynedd.
Abstract
When `catastrophic' is applied as an adjective to the antiphospholipid syndrome, it implies a characteristic presentation due to predominantly small blood vessel thrombosis leading to rapidly progressive failure of multiple organs and a frequently fatal outcome. We present the case of a 48year-old woman who presented with the `catastrophic' antiphospholipid syndrome without previous history of coagulation disorder or connective tissue disease that illustrates the difficulties in diagnosing and managing this disorder. We also review the factors that have been reported to have a role in the development of this condition and show how this case throws light on its pathogenesis.
Url:
DOI: 10.1177/096120330000900702
Affiliations:
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Ahmed</name></author><author wicri:is="90%"><name sortKey="Whiteley, G S" sort="Whiteley, G S" uniqKey="Whiteley G" first="G S" last="Whiteley">G S Whiteley</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Gwynedd Rheumatology Service, Ysbyty Gwynedd, Bangor</wicri:regionArea><wicri:noRegion>Bangor</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Lupus</title><idno type="ISSN">0961-2033</idno><idno type="eISSN">1477-0962</idno><imprint><publisher>Sage Publications</publisher><pubPlace>Sage CA: Thousand Oaks, CA</pubPlace><date type="published" when="2000-09">2000-09</date><biblScope unit="volume">9</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="484">484</biblScope><biblScope unit="page" to="488">488</biblScope></imprint><idno type="ISSN">0961-2033</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0961-2033</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Active phase</term><term>Anticardiolipin</term><term>Anticardiolipin antibodies</term><term>Anticardiolipin antibody</term><term>Antiphospholipid</term><term>Antiphospholipid antibodies</term><term>Antiphospholipid syndrome</term><term>Arthritis rheum</term><term>Asherson</term><term>Catastrophic antiphospholipid syndrome</term><term>Clinical course</term><term>Clinical features</term><term>Clinical picture</term><term>Coagulation</term><term>Deep venous thrombosis</term><term>Distress syndrome</term><term>Erythematosus</term><term>Gastrointestinal features</term><term>Gwynedd rheumatology service</term><term>High degree</term><term>High dose</term><term>Hypercoagulable disorder</term><term>Intensive care</term><term>Intensive care unit</term><term>Liver function tests</term><term>Lung compliance</term><term>Lupus</term><term>Microangiopathic haemolytic anaemia</term><term>Motor neuropathy</term><term>Multiple organs</term><term>Neurological manifestations</term><term>Platelet count</term><term>Previous history</term><term>Progressive failure</term><term>Rheumatoid factor</term><term>Rheumatol</term><term>Syndrome</term><term>Systemic</term><term>Systemic lupus erythematosus</term><term>Thrombosis</term><term>Thrombotic</term><term>Thrombotic storm</term><term>Transient improvement</term><term>Vascular endothelium</term><term>Ysbyty gwynedd</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">When `catastrophic' is applied as an adjective to the antiphospholipid syndrome, it implies a characteristic presentation due to predominantly small blood vessel thrombosis leading to rapidly progressive failure of multiple organs and a frequently fatal outcome. We present the case of a 48year-old woman who presented with the `catastrophic' antiphospholipid syndrome without previous history of coagulation disorder or connective tissue disease that illustrates the difficulties in diagnosing and managing this disorder. We also review the factors that have been reported to have a role in the development of this condition and show how this case throws light on its pathogenesis.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Ahmed, W" sort="Ahmed, W" uniqKey="Ahmed W" first="W" last="Ahmed">W. Ahmed</name><name sortKey="Seale, J R C" sort="Seale, J R C" uniqKey="Seale J" first="J R C" last="Seale">J R C. Seale</name><name sortKey="Thorpe, C" sort="Thorpe, C" uniqKey="Thorpe C" first="C" last="Thorpe">C. Thorpe</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Maddison, P J" sort="Maddison, P J" uniqKey="Maddison P" first="P J" last="Maddison">P J Maddison</name></noRegion><name sortKey="Maddison, P J" sort="Maddison, P J" uniqKey="Maddison P" first="P J" last="Maddison">P J Maddison</name><name sortKey="Whiteley, G S" sort="Whiteley, G S" uniqKey="Whiteley G" first="G S" last="Whiteley">G S Whiteley</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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